Here, we identify general and cell-line-specific requirements for NANOG, OCT4, and SOX2 in hESCs. The target genes of each transcription factor overlap extensively: POU5F1, SOX2, and NANOG co-occupy at least 353 genes (Boyer et al.

2005). We show that OCT4 regulates, and interacts with, the BMP4 pathway to specify four developmental …

POU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of target genes. 2005). However, the mechanisms by which these factors control cell fate, and their interactions with one another are not fully understood.
Although their basic importance in human (h)ESCs has been demonstrated, the mechanistic functions are not well defined.

2005). Transcription factors NANOG, OCT4, and SOX2 regulate self-renewal and pluripotency in human embryonic stem (hES) cells; however, their expression profiles during early differentiation of hES cells are unclear. We found that expression levels of Nanog, Oct4, Sox2, PCNA, Ki67 and E-cadherin were …

The transcriptional activators Oct4, Sox2, and Nanog cooperate with a wide array of cofactors to orchestrate an embryonic stem (ES) cell-specific gene expression program … About half of POU5F1 targets also bind SOX2 and about 90% of these also bind NANOG (Boyer et al.

POU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of target genes. Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. The target genes of each transcription factor overlap extensively: POU5F1, SOX2, and NANOG co-occupy at least 353 genes (Boyer et al.

Nanog, Oct4, and Sox2 are the core regulators of mouse (m)ESC pluripotency. Abstract. The purpose of this study was to evaluate expression and prognostic impact of Nanog, Oct4, Sox2, proliferation cell nuclear antigen (PCNA), Ki67 and E-cadherin in patients with gastric cancer (GC) by immunohistochemistry.

The pluripotency transcription factors (TFs) Nanog, Sox2, and Oct4 are at the centre of the gene regulatory network that controls cell identity in embryonic stem (ES) cells.
2005). A total of 69 patients were recruited who underwent gastrectomy between 2008 and 2009. About half of POU5F1 targets also bind SOX2 and about 90% of these also bind NANOG (Boyer et al.


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