“Histamine 2 blockers (also called H2 blockers) ... Certain lactobacillus strains – some more than others and some are also the opposite of what you want. There are some reports apparently about this yeast causing histamine issues in some people, but it has been used for detoxifying gliotoxin and apparently increases DAO production which means it should help with histamine issues. L. Paracasei has been shown to possibly help with leaky gut or allergies (source) Low-Histamine Probiotics Lactobacilli can therefore use a variety of mechanisms to inhibit mast cells activation.

However, the ATCC 393 strain was found to NOT produce tyramine when exposed to tyrosine and some strains actually degrade the biogenic amines in vitro . Saccharomyces-Boulardii – This is a low histamine probiotic that also helps regulate digestive issues, like diarrhea. After a few years of research, I’ve identified which strains of probiotics support those with histamine intolerance. • The probiotic Lactobacillus paracasei CASEI 431® (not to be confused with Lactobacillus casei as they are completely different species), has been tested and found not to produce histamine. If you must have a histamine increasing probiotic, these two have the most benefits: Lactobacillus Helveticus (reduces anxiety and ammonia, restores cognitive function) Lactobacillus Reuteri (reduces intestinal inflammation, increases pain tolerance & bowel function) L. casei has a bad reputation of being dangerous for people with histamine intolerance. As a species, Lactobacillus casei may or may not produce biogenic amines like histamine and tyramine. In addition to raising histamine, it also is helpful in increasing levels of anti-inflammatory cyclic adenosine monophosphate (cAMP).

Similarly another strain of L. paracasei inhibited mast cell granule formation 35, and strains of L. rhamnosus downregulated high‐affinity IgE receptor FCER1A, and histamine receptor HRH4 genes expression 36. Lactobacillus lactis – This strain is still being debated by scientists and medical professionals.

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